Form of Proxy

Election of Director to hold office until the 2029 Annual General Meeting of Shareholders: Bruce C. Cozadd

Election of Director to hold office until the 2029 Annual General Meeting of Shareholders: Heather Ann McSharry

Election of Director to hold office until the 2029 Annual General Meeting of Shareholders: Rick E Winningham

To ratify, on a non-binding advisory basis, the appointment of KPMG as the independent auditors of Jazz Pharmaceuticals plc for the fiscal year ending December 31, 2026 and to authorize, in a binding vote, the Board of Directors, acting through the audit committee, to determine KPMGs remuneration.

To approve, on a non-binding advisory basis, the compensation of Jazz Pharmaceuticals plcs named executive officers as disclosed in the proxy statement.

To grant the Board of Directors authority under Irish law to allot and issue ordinary shares.

To grant the Board of Directors authority under Irish law to allot and issue ordinary shares for cash without first offering those ordinary shares to existing shareholders pursuant to the statutory pre-emption right that would otherwise apply.

To approve any motion to adjourn the Annual General Meeting, or any adjournments thereof, to another time and place to solicit additional proxies if there are insufficient votes at the time of the Annual General Meeting to approve either Proposal 4 or Proposal 5.