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Form of Proxy

MILESTONE PHARMACEUTICALS INC.

Notes

No. Proposition For Against Abstain
1

Election of Director: Stuart M. Duty

2

Election of Director: Seth H.Z. Fischer

3

Election of Director: Lisa M. Giles

4

Election of Director: Joseph Oliveto

5

Election of Director: Joseph C. Papa

6

Election of Director: Andrew R. Saik

7

Election of Director: Michael Tomsicek

8

Election of Director: Robert J. Wills, PhD

9

Appointment of Auditors: Ratification of the selection of PricewaterhouseCoopers LLP as auditor for the Company until the close of the 2027 Annual Meeting of Shareholders and the Board of Directors of the Company is hereby authorized to fix the auditors remuneration.

10

2019 Equity Incentive Plan Amendment: Approval of the Companys 2019 Equity Incentive Plan, as amended, to increase the number of shares authorized for issuance by 6.8 million shares.

11

Say-on-Pay: A non-binding advisory vote on the compensation of the Companys named executive officers.