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Form of Proxy

SUMMIT THERAPEUTICS INC.

Notes

No. Proposition For Against Abstain
1

DIRECTOR Robert W. Duggan

2

DIRECTOR Mahkam Zanganeh

3

DIRECTOR Manmeet S. Soni

4

DIRECTOR Kenneth A. Clark

5

DIRECTOR Robert Booth

6

DIRECTOR Alessandra Cesano

7

DIRECTOR Yu (Michelle) Xia

8

DIRECTOR Mostafa Ronaghi

9

DIRECTOR Jeff Huber

10

Ratification of the appointment of PricewaterhouseCoopers LLP as Independent Registered Public Accounting Firm for the fiscal year ending December 31, 2026.

11

Approval, by a non-binding advisory vote, of the compensation of our named executive officers.

12

Approval of an amendment to the Summit Therapeutics Inc. 2020 Stock Incentive Plan to Increase the Number of Shares of Common Stock.