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Form of Proxy

SCHRODINGER, INC.

Notes

No. Proposition For Against Abstain
1

Election of Class III Director to serve until the 2029 Annual Meeting of Stockholders: Richard A. Friesner

2

Election of Class III Director to serve until the 2029 Annual Meeting of Stockholders: Rosana Kapeller-Libermann

3

Election of Class III Director to serve until the 2029 Annual Meeting of Stockholders: Gary Sender

4

Approval of an advisory vote on executive compensation.

5

Approval of an amendment to the Schrödinger, Inc. 2022 Equity Incentive Plan, as amended, to increase the number of shares of common stock available for issuance thereunder by 3,000,000 shares.

6

Ratification of the appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026.