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Form of Proxy

CURIS, INC.

Notes

No. Proposition For Against Abstain
1

DIRECTOR Martyn D. Greenacre

2

DIRECTOR Kenneth I. Kaitin, Ph.D

3

To approve, on an advisory (non-binding) basis, the compensation of our named executive officers.

4

To ratify the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026.

5

To adopt and approve an amendment to our Restated Certificate of Incorporation, as amended, to increase the number of authorized shares of our common stock.

6

To approve an adjournment of the annual meeting, if necessary, to solicit additional proxies in the event there are insufficient votes to approve Proposal 4.