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Form of Proxy

SKYE BIOSCIENCE, INC.

Notes

No. Proposition For Against Abstain
1

DIRECTOR Paul Grayson

2

DIRECTOR Deborah Charych

3

DIRECTOR Punit Dhillon

4

DIRECTOR Annalisa Jenkins

5

DIRECTOR Karen Smith

6

DIRECTOR Andrew J. Schwab

7

Consider and vote upon the ratification of the selection of CBIZ CPAs P.C. as our independent registered public accounting firm for the year ending December 31, 2026.

8

To consider and vote upon the approval of an amendment to our Articles of Incorporation to increase the number of authorized shares of our common stock from 100,000,000 to 300,000,000.

9

Consider and vote upon, on an advisory basis, the compensation of our named executive officers as disclosed in the accompanying proxy statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission.