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Form of Proxy

VERTEX PHARMACEUTICALS INCORPORATED

Notes

No. Proposition For Against Abstain
1

Election of Director: Sangeeta Bhatia

2

Election of Director: Lloyd Carney

3

Election of Director: Alan Garber

4

Election of Director: Reshma Kewalramani

5

Election of Director: Michel Lagarde

6

Election of Director: Jeffrey Leiden

7

Election of Director: Diana McKenzie

8

Election of Director: Bruce Sachs

9

Election of Director: Jennifer Schneider

10

Election of Director: Nancy Thornberry

11

Election of Director: Suketu Upadhyay

12

Ratification of Ernst & Young LLP as independent Registered Public Accounting firm for the year ending December 31, 2026.

13

Advisory vote to approve named executive officer compensation.

14

Approval of 2026 Stock and Option Plan.

15

Shareholder proposal, if properly presented at the meeting, regarding shareholder right to act by written consent.