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Form of Proxy

ALNYLAM PHARMACEUTICALS, INC.

Notes

No. Proposition For Against Abstain
1

Election of Class I Director of Alnylam to serve for a term ending in 2029: Stuart A. Arbuckle

2

Election of Class I Director of Alnylam to serve for a term ending in 2029: Yvonne L. Greenstreet, M.D.

3

Election of Class I Director of Alnylam to serve for a term ending in 2029: Elliott Sigal M.D., Ph.D.

4

To approve, in a non-binding advisory vote, the compensation of Alnylams named executive officers.

5

To ratify the appointment of PricewaterhouseCoopers LLP, an independent registered public accounting firm, as Alnylams independent auditors for the fiscal year ending December 31, 2026.