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Form of Proxy

ONCOLYTICS BIOTECH INC.

Notes

No. Proposition For Against Abstain
1

To consider and, if thought advisable, pass, with or without variation, a special resolution authorizing the continuance of the Corporation from the Province of Alberta under the Business Corporations Act (Alberta) to the Province of British Columbia under the Business Corporations Act (British Columbia) (the Continuance), subject to and conditional upon the approval of the Domestication Resolution (as described below).

2

To consider and, if thought advisable, pass, with or without variation, a special resolution authorizing the continuation of the Corporation out of the Province of British Columbia and domestication to the State of Nevada and the adoption of the articles of domestication and new articles of incorporation (the Domestication), subject to and conditional upon the approval of the Continuance Resolution (as described above).

3

To consider and, if thought advisable, approve, subject to and conditional upon the completion of the Continuance and Domestication, the 2026 Incentive Award Plan.