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Form of Proxy

EXACT SCIENCES CORPORATION

Notes

No. Proposition For Against Abstain
1

Election of Director to serve for one-year term (to serve until his or her successor is elected and qualified or until his or her earlier death, resignation or removal): Michael Barber

2

Election of Director to serve for one-year term (to serve until his or her successor is elected and qualified or until his or her earlier death, resignation or removal): Paul Clancy

3

Election of Director to serve for one-year term (to serve until his or her successor is elected and qualified or until his or her earlier death, resignation or removal): Daniel Levangie

4

Election of Director to serve for one-year term (to serve until his or her successor is elected and qualified or until his or her earlier death, resignation or removal): Kevin Conroy

5

Election of Director to serve for one-year term (to serve until his or her successor is elected and qualified or until his or her earlier death, resignation or removal): Shacey Petrovic

6

Election of Director to serve for one-year term (to serve until his or her successor is elected and qualified or until his or her earlier death, resignation or removal): Kimberly Popovits

7

Election of Director to serve for one-year term (to serve until his or her successor is elected and qualified or until his or her earlier death, resignation or removal): Katherine Zanotti

8

To ratify the selection of PricewaterhouseCoopers LLP as our independent registered public accounting firm for 2025.

9

To approve, on an advisory basis, the compensation of our named executive officers.

10

To approve the 2025 Omnibus Long-Term Incentive Plan.

11

To approve an Amendment to the 2010 Employee Stock Purchase Plan to add 4,000,000 shares of stock to the pool of shares available for purchase by employees.

12

To vote on a shareholder proposal concerning the adoption of a director election resignation governance policy, if properly presented.