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Form of Proxy

SKYE BIOSCIENCE, INC.

Notes

No. Proposition For Against Abstain
1

DIRECTOR Paul Grayson

2

DIRECTOR Deborah Charych

3

DIRECTOR Punit Dhillon

4

DIRECTOR Annalisa Jenkins

5

DIRECTOR Karen Smith

6

DIRECTOR Andrew J. Schwab

7

Consider and vote upon the ratification of the selection of Marcum LLP as our independent registered public accounting firm for the year ending December 31, 2025.

8

Consider and vote upon, on an advisory basis, the compensation of our named executive officers as disclosed in this proxy statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission.

9

Consider and vote upon, on an advisory basis, whether the stockholder vote to approve the compensation of the named executive officers as required by Section 14A(a)(2) of the Securities Exchange Act of 1934, as amended, should occur every one, two or three years.