Election of Director: Allene M. Diaz
Election of Director: Michael Hayden
Election of Director: Joseph Klein, III
Election of Director: Joseph Loscalzo
To make an advisory vote on executive compensation.
To approve an amendment of the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan to increase the aggregate number of shares of common stock authorized for issuance under such plan by 4,000,000 shares to an aggregate of 42,500,000 shares.
To ratify the Audit Committees selection of Ernst & Young LLP as independent auditors for the 2025 fiscal year.