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Form of Proxy

CUE BIOPHARMA, INC.

Notes

No. Proposition For Against Abstain
1

To adopt and approve an amendment to our Amended and Restated Certificate of Incorporation, as amended, to increase the number of authorized shares of our capital stock from 210,000,000 to 310,000,000 and increase the number of authorized shares of our common stock from 200,000,000 to 300,000,000.

2

Election of Director: Daniel R. Passeri

3

Election of Director: Peter A. Kiener

4

Election of Director: Frank Morich

5

Election of Director: Pamela Garzone

6

Election of Director: Patrick Verheyen

7

Election of Director: Pasha Sarraf

8

The ratification of the appointment of RSM US LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.

9

The approval, on a non-binding advisory basis, of the compensation of our named executive officers.

10

The approval of the Cue Biopharma, Inc. 2025 Stock Incentive Plan.