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Form of Proxy

MARKETAXESS HOLDINGS INC.

Notes

No. Proposition For Against Abstain
1

Election of Director: Carlos M. Hernandez

2

Election of Director: Christopher R. Concannon

3

Election of Director: Nancy Altobello

4

Election of Director: Steven L. Begleiter

5

Election of Director: Stephen P. Casper

6

Election of Director: Jane Chwick

7

Election of Director: William F. Cruger

8

Election of Director: Kourtney Gibson

9

Election of Director: Roberto Hoornweg

10

Election of Director: Richard G. Ketchum

11

Election of Director: Emily H. Portney

12

To ratify the appointment of PricewaterhouseCoopers LLP as the Companys independent registered public accounting firm for the year ending December 31, 2025.

13

To approve, on an advisory basis, the compensation of the Companys named executive officers as disclosed in the 2025 Proxy Statement.

14

If properly presented, a stockholder proposal to remove the one-year holding period requirement to call a special stockholder meeting.