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Form of Proxy

CURIS, INC.

Notes

No. Proposition For Against Abstain
1

DIRECTOR John A. Hohneker, M.D.

2

DIRECTOR Marc Rubin, M.D.

3

To approve an advisory vote on executive compensation.

4

To ratify the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.

5

To approve Amendment No. 1 to the Fifth Amended and Restated 2010 Stock Incentive Plan to reserve up to an additional 1,255,000 shares of common stock for issuance under the plan.

6

To adopt and approve an amendment to our Restated Certificate of Incorporation, as amended, to increase the number of authorized shares of our capital stock from 39,171,875 to 73,343,750 and the number of authorized shares of our common stock from 34,171,875 to 68,343,750.

7

To approve, in accordance with Nasdaq Listing Rule 5635(d), the issuance of up to 8,316,882 shares of our common stock upon the exercise of certain warrants issued on March 31, 2025 in a private placement.